The Clinical Pharmacokinetics department is responsible for providing input into clinical study design and methodology, evaluating, interpreting and reporting pharmacokinetic, pharmacodynamic and biopharmaceutical data, for therapeutic research studies, in compliance with Good Clinical Practice standards.
The Clinical Pharmacokinetic department is also primarily involved in mathematical modelling of non-clinical and clinical data: combining pharmacokinetic, i.e., ‘how the body processes a drug’ and pharmacodynamic, i.e., ‘how the drug acts on the body’ ideas leads to the concept of dose-concentration-effect, which can be modelled using pharmacokinetic pharmacodynamic modelling. The result of such modelling is a mathematical description of a drug’s fate in the body, for an individual. Population modelling involves the analysis of data from a group (population) of individuals, with all their data analysed simultaneously to provide information about the variability of model parameters. Appropriate methods of analysis (i.e., pharmacometrics) of such data require an understanding of the underlying science including: anatomy, physiology, chemistry, biostatistics and computational methods. Modelling and simulation furnish scientists with a conceptual tool for translating often complex, real-world subject matter into a simplified form (a mathematical model) that is used to describe, explain, investigate and predict the behaviour of a drug in a given situation.
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Last Updated 19/06/2008 16:54:00
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